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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. A 58-year-old woman presents to the emergency department of a small rural hospital with recurrent chest pain that is unrelieved by three sublingual nitroglycerin tablets. Initial evaluation of her ECG and cardiac enzymes are consistent with non-STEMI. The woman is admitted for observation and given aspirin. Which of the following should be added to this patient's regimen to reduce her risk of death, MI, and recurrent ischemia?

A) Intravenous t-PA
B) Subcutaneous enoxaparin
C) Subcutaneous heparin
D) Oral warfarin

2. A 58-year-old man presents complaining of unsteady gait. Past medical history is significant for diabetes mellitus, gastroparesis, and depression. The patient exhibits a slight shuffling gait, mild limb rigidity, and decreased speed in performing rapid alternating movement. Current daily medications are bupropion, glyburide, metoclopramide, and omeprazole. Which of the following would be the most appropriate initial management for the presenting complaint?

A) Begin ropinirole.
B) Discontinue metoclopramide.
C) Discontinue bupropion.
D) Begin carbidopa/levodopa.

3. A pharmacotherapy specialist is conducting a pharmacokinetic study of a drug. The pharmacokinetic profile of this drug is best described by a one-compartment model with a mean elimination rate constant of 0.173/h. The standard curve for the assay to be used covers the range of 5-40mcg/mL. Samples are collected shortly after single intravenous bolus drug administration, and at 4 and 8 hours after dosing. Preliminary analysis shows that the 4-hour sample concentration is 25 mcg/mL. In this situation, which of the following statements is correct?

A) The initial plasma concentration is probably outside the range of the standard curve' it may be possible to dilute the sample and re-assay.
B) All plasma concentrations are probably within the range of the standard curve and can be reliably measured.
C) Both the initial and 8-hour concentration points are probably outside the range of the standard curve but can be reliably quantitated by extrapolating the curve to higher and lower points.
D) Both the initial and 8-hour concentration points are probably outside the range of the standard curve and cannot be reliably measured without diluting the samples.

4. A patient presents with palpitations and shortness of breath. A 12-lead ECG reveals a regular narrow QRS complex supraventricular tachycardia. What is the recommended first-line therapy?

A) Adenosine
B) Verapamil
C) Lidocaine
D) Amiodarone

5. Which of the following is an example of a sentinel event, as defined by the Joint Commission?

A) Death due to heart failure following discharge against medical advice
B) Administration of digoxin to the Wrong patient without adverse events
C) Removal of the Wrong breast during surgery
D) Death due to overdose of methylphenidate obtained from a brother's prescription

Solutions: